Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency

Defective lysosomal function defines many neurodegenerative diseases, such as neuronal ceroid lipofuscinoses (NCL) and Niemann-Pick type C (NPC), and is implicated in Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD-TDP) with progranulin (PGRN) deficiency. Here, we show that PGRN...

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Hlavní autoři: Bret M. Evers, Carlos Rodriguez-Navas, Rachel J. Tesla, Janine Prange-Kiel, Catherine R. Wasser, Kyoung Shin Yoo, Jeffrey McDonald, Basar Cenik, Thomas A. Ravenscroft, Florian Plattner, Rosa Rademakers, Gang Yu, Charles L. White, III, Joachim Herz
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2017-09-01
Edice:Cell Reports
Témata:
neurodegeneration
Alzheimer’s disease
frontotemporal lobar degeneration
lipids
lipidomics
transcriptomics
lysosome
lysosomal storage disorders
neuronal ceroid lipofuscinoses
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2211124717311816
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