Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency

Defective lysosomal function defines many neurodegenerative diseases, such as neuronal ceroid lipofuscinoses (NCL) and Niemann-Pick type C (NPC), and is implicated in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD-TDP) with progranulin (PGRN) deficiency. Here, we show that...

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發表在:Cell Rep
Main Authors: Evers, Bret M., Rodriguez-Navas, Carlos, Tesla, Rachel J., Prange-Kiel, Janine, Wasser, Catherine R., Yoo, Kyoung Shin, McDonald, Jeffrey, Cenik, Basar, Ravenscroft, Thomas A., Plattner, Florian, Rademakers, Rosa, Yu, Gang, White, Charles L., Herz, Joachim
格式: Artigo
語言:Inglês
出版: 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5757843/
https://ncbi.nlm.nih.gov/pubmed/28903038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.056
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