Molecular testing for Lynch syndrome in people with colorectal cancer: systematic reviews and economic evaluation

Background: Inherited mutations in deoxyribonucleic acid (DNA) mismatch repair (MMR) genes lead to an increased risk of colorectal cancer (CRC), gynaecological cancers and other cancers, known as Lynch syndrome (LS). Risk-reducing interventions can be offered to individuals with known LS-causing mut...

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Detalhes bibliográficos
Main Authors: Tristan Snowsill, Helen Coelho, Nicola Huxley, Tracey Jones-Hughes, Simon Briscoe, Ian M Frayling, Chris Hyde
Formato: Artigo
Idioma:Inglês
Publicado em: NIHR Journals Library 2017-09-01
Colecção:Health Technology Assessment
Assuntos:
lynch syndrome
hereditary non-polyposis colorectal cancer
colorectal cancer
microsatellite instability testing
immunohistochemistry
systematic review
diagnostic accuracy
cost-effectiveness analysis
decision modelling
cost–utility analysis
Acesso em linha:https://doi.org/10.3310/hta21510
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