Molecular testing for Lynch syndrome in people with colorectal cancer: systematic reviews and economic evaluation.

BACKGROUND: Inherited mutations in deoxyribonucleic acid (DNA) mismatch repair (MMR) genes lead to an increased risk of colorectal cancer (CRC), gynaecological cancers and other cancers, known as Lynch syndrome (LS). Risk-reducing interventions can be offered to individuals with known LS-causing mut...

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Detalhes bibliográficos
Publicado no:Health Technol Assess
Main Authors: Snowsill, Tristan, Coelho, Helen, Huxley, Nicola, Jones-Hughes, Tracey, Briscoe, Simon, Frayling, Ian M, Hyde, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: NIHR Journals Library 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5611555/
https://ncbi.nlm.nih.gov/pubmed/28895526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3310/hta21510
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