Germline and somatic variations influence the somatic mutational signatures of esophageal squamous cell carcinomas in a Chinese population

Abstract Background Esophageal squamous cell carcinomas (ESCC) is the fourth most lethal cancer in China. Previous studies reveal several highly conserved mutational processes in ESCC. However, it remains unclear what are the true regulators of the mutational processes. Results We analyzed the somat...

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Библиографические подробности
Главные авторы: Jintao Guo, Jiankun Huang, Ying Zhou, Yulin Zhou, Liying Yu, Huili Li, Lingyun Hou, Liuwei Zhu, Dandan Ge, Yuanyuan Zeng, Bayasi Guleng, Qiyuan Li
Формат: Artigo
Язык:Inglês
Опубликовано: BMC 2018-07-01
Серии:BMC Genomics
Предметы:
Esophageal squamous cell carcinomas
ZNF750
CDC27
Mutational signature
Genetic burden
Online-ссылка:http://link.springer.com/article/10.1186/s12864-018-4906-4
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