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Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice
Abstract Background Current therapies fail to cure over a third of osteosarcoma patients and around three quarters of those with metastatic disease. “Smac mimetics” (also known as “IAP antagonists”) are a new class of anti-cancer agents. Previous work revealed that cells from murine osteosarcomas we...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
BMC
2019-09-01
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| 叢編: | BMC Cancer |
| 主題: | |
| 在線閱讀: | http://link.springer.com/article/10.1186/s12885-019-6103-5 |
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