CD4+ T follicular helper and IgA+ B cell numbers in gut biopsies from HIV-infected subjects on antiretroviral therapy are comparable to HIV-uninfected individuals

Background: Disruption of gastrointestinal tract epithelial and immune barriers contribute to microbial translocation, systemic inflammation and progression of HIV-1 infection. Antiretroviral therapy (ART) may lead to reconstitution of CD4+ T cells in gastrointestinal-associated lymphoid tissue (GAL...

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Main Authors: John Zaunders, Mark Danta, Michelle Bailey, Gerald Mak, Katherine Marks, Nabila Seddiki, Yin Xu, David J Templeton, David A Cooper, Mark A Boyd, Anthony Dominic Kelleher, Kersten K Koelsch
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016-10-01
Colecção:Frontiers in Immunology
Assuntos:
HIV
Gut-associated lymphoid tissue
T follicular helper cells
CD4+ T lymphocytes
Germinal centres
IgA B cells
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00438/full
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