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The Ubiquitin-Proteasome Pathway in Huntington's Disease
The accumulation of mutant protein is a common feature of neurodegenerative disease. In Huntington's disease, a polyglutamine expansion in the huntingtin protein triggers neuronal toxicity. Accompanying neuronal death, mutant huntingtin aggregates in large macromolecular structures called inclu...
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| Huvudupphovsmän: | , |
|---|---|
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Hindawi Limited
2008-01-01
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| Serie: | The Scientific World Journal |
| Länkar: | http://dx.doi.org/10.1100/tsw.2008.60 |
| Taggar: |
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