Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia

Schizophrenia (SZ) is a severe psychiatric disorder; unfortunately, only ~1/3 of patients respond favorably to treatment. Here, the authors reveal hyperacetylation of histone H2A.Z in SZ neurons and postmortem SZ human brain tissues. They further show BRD4 is a reader of hyperacetylated H2A.Z and tr...

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Detalhes bibliográficos
Main Authors: Lorna A. Farrelly, Shuangping Zheng, Nadine Schrode, Aaron Topol, Natarajan V. Bhanu, Ryan M. Bastle, Aarthi Ramakrishnan, Jennifer C Chan, Bulent Cetin, Erin Flaherty, Li Shen, Kelly Gleason, Carol A. Tamminga, Benjamin A. Garcia, Haitao Li, Kristen J. Brennand, Ian Maze
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2022-04-01
Colecção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-022-29922-0
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