Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection

Islet inflammation and cytokine production are implicated in pancreatic β-cell dysfunction and diabetes pathogenesis. However, we lack therapeutics to protect the insulin-producing β-cells from inflammatory damage. Closing this clinical gap requires the establishment of new disease models of islet i...

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Bibliografische gegevens
Hoofdauteurs: Luis Fernando Delgadillo-Silva, Anastasia Tsakmaki, Nadeem Akhtar, Zara J. Franklin, Judith Konantz, Gavin A. Bewick, Nikolay Ninov
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Company of Biologists 2019-01-01
Reeks:Disease Models & Mechanisms
Onderwerpen:
Diabetes
Inflammation
Insulin
Islet
Regeneration
Zebrafish
Beta-cells
Online toegang:http://dmm.biologists.org/content/12/1/dmm036004
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