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Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection

Islet inflammation and cytokine production are implicated in pancreatic β-cell dysfunction and diabetes pathogenesis. However, we lack therapeutics to protect the insulin-producing β-cells from inflammatory damage. Closing this clinical gap requires the establishment of new disease models of islet i...

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Autors principals: Luis Fernando Delgadillo-Silva, Anastasia Tsakmaki, Nadeem Akhtar, Zara J. Franklin, Judith Konantz, Gavin A. Bewick, Nikolay Ninov
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists 2019-01-01
Col·lecció:Disease Models & Mechanisms
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Accés en línia:http://dmm.biologists.org/content/12/1/dmm036004
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