Reprogramming somatic cells to cells with neuronal characteristics by defined medium both in vitro and in vivo

Background: Currently, direct conversion from somatic cells to neurons requires virus-mediated delivery of at least one transcriptional factor or a combination of several small-molecule compounds. Delivery of transcriptional factors may affect genome stability, while small-molecule compounds may req...

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Main Authors: Songwei He, Yiping Guo, Yixin Zhang, Yuan Li, Chengqian Feng, Xiang Li, Lilong Lin, Lin Guo, Haitao Wang, Chunhua Liu, Yi Zheng, Chuanming Luo, Qiang Liu, Fuhui Wang, Hao Sun, Lining Liang, Lingyu Li, Huanxing Su, Jiekai Chen, Duanqing Pei, Hui Zheng
Formato: Artigo
Idioma:Inglês
Publicado em: SpringerOpen 2015-01-01
Colecção:Cell Regeneration
Assuntos:
Neurons
Somatic cells
Astrocytes
Trans-differentiation
Defined medium
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2045976917300159
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