Lysine-specific histone demethylase 1 inhibition promotes reprogramming by facilitating the expression of exogenous transcriptional factors and metabolic switch

Lysine-specific histone demethylase 1 (LSD1) regulates histone methylation and influences the epigenetic state of cells during the generation of induced pluripotent stem cells (iPSCs). Here we reported that LSD1 inhibition via shRNA or specific inhibitor, tranylcypromine, promoted reprogramming at e...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sun, Hao, Liang, Lining, Li, Yuan, Feng, Chengqian, Li, Lingyu, Zhang, Yixin, He, Songwei, Pei, Duanqing, Guo, Yunqian, Zheng, Hui
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4969595/
https://ncbi.nlm.nih.gov/pubmed/27481483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30903
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