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Estimation of parent specific DNA copy number in tumors using high-density genotyping arrays.

Chromosomal gains and losses comprise an important type of genetic change in tumors, and can now be assayed using microarray hybridization-based experiments. Most current statistical models for DNA copy number estimate total copy number, which do not distinguish between the underlying quantities of...

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Bibliografske podrobnosti
Main Authors: Hao Chen, Haipeng Xing, Nancy R Zhang
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2011-01-01
Serija:PLoS Computational Biology
Online dostop:http://europepmc.org/articles/PMC3029233?pdf=render
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