Drug-induced regulation of target expression.

Drug perturbations of human cells lead to complex responses upon target binding. One of the known mechanisms is a (positive or negative) feedback loop that adjusts the expression level of the respective target protein. To quantify this mechanism systems-wide in an unbiased way, drug-induced differen...

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Autores principales: Murat Iskar, Monica Campillos, Michael Kuhn, Lars Juhl Jensen, Vera van Noort, Peer Bork
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2010-09-01
Colección:PLoS Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20838579/pdf/?tool=EBI
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