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Network Neighbors of Drug Targets Contribute to Drug Side-Effect Similarity

In pharmacology, it is essential to identify the molecular mechanisms of drug action in order to understand adverse side effects. These adverse side effects have been used to infer whether two drugs share a target protein. However, side-effect similarity of drugs could also be caused by their target...

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Detalhes bibliográficos
Main Authors: Brouwers, Lucas, Iskar, Murat, Zeller, Georg, van Noort, Vera, Bork, Peer
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135612/
https://ncbi.nlm.nih.gov/pubmed/21765950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022187
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