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Network Neighbors of Drug Targets Contribute to Drug Side-Effect Similarity

In pharmacology, it is essential to identify the molecular mechanisms of drug action in order to understand adverse side effects. These adverse side effects have been used to infer whether two drugs share a target protein. However, side-effect similarity of drugs could also be caused by their target...

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Autori principali: Brouwers, Lucas, Iskar, Murat, Zeller, Georg, van Noort, Vera, Bork, Peer
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135612/
https://ncbi.nlm.nih.gov/pubmed/21765950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022187
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