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Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts.

RNA-dependent RNA polymerases play a vital role in the growth of RNA viruses where they are responsible for genome replication, but do so with rather low fidelity that allows for the rapid adaptation to different host cell environments. These polymerases are also a target for antiviral drug developm...

詳細記述

保存先:
書誌詳細
主要な著者: Peng Gong, Matthew G Kortus, Jay C Nix, Ralph E Davis, Olve B Peersen
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science (PLoS) 2013-01-01
シリーズ:PLoS ONE
オンライン・アクセス:http://europepmc.org/articles/PMC3648537?pdf=render
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