Concurrent Label-Free Mass Spectrometric Analysis of Dystrophin Isoform Dp427 and the Myofibrosis Marker Collagen in Crude Extracts from mdx-4cv Skeletal Muscles

The full-length dystrophin protein isoform of 427 kDa (Dp427), the absence of which represents the principal abnormality in X-linked muscular dystrophy, is difficult to identify and characterize by routine proteomic screening approaches of crude tissue extracts. This is probably related to its large...

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Autors principals: Sandra Murphy, Margit Zweyer, Rustam R. Mundegar, Michael Henry, Paula Meleady, Dieter Swandulla, Kay Ohlendieck
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2015-09-01
Col·lecció:Proteomes
Matèries:
collagen
Dp427
Duchenne muscular dystrophy
dystrophin
myofibrosis
Accés en línia:http://www.mdpi.com/2227-7382/3/3/298
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