The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors.

Hepatitis C virus (HCV) infects over 170 million people worldwide and is the leading cause of chronic liver diseases, including cirrhosis, liver failure, and liver cancer. Available antiviral therapies cause severe side effects and are effective only for a subset of patients, though treatment outcom...

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Main Authors: Keith P Romano, Akbar Ali, Cihan Aydin, Djade Soumana, Ayşegül Ozen, Laura M Deveau, Casey Silver, Hong Cao, Alicia Newton, Christos J Petropoulos, Wei Huang, Celia A Schiffer
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2012-01-01
Colecção:PLoS Pathogens
Acesso em linha:http://europepmc.org/articles/PMC3406087?pdf=render
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