Hsp90 S-nitrosylation at Cys521, as a conformational switch, modulates cycling of Hsp90-AHA1-CDC37 chaperone machine to aggravate atherosclerosis

Endothelial dysfunction is the initial process of atherosclerosis. Heat shock protein 90 (Hsp90), as a molecular chaperone, plays a crucial role in various cardiovascular diseases. Hsp90 function is regulated by S-nitrosylation (SNO). However, the precise role of SNO-Hsp90 in endothelial dysfunction...

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Hlavní autoři: Shuang Zhao, Xin Tang, Zian Miao, Yurong Chen, Jiawei Cao, Tianyu Song, Daiting You, Yanqing Zhong, Zhe Lin, Dan Wang, Zhiguang Shi, Xinlong Tang, Dongjin Wang, Shaoliang Chen, Liansheng Wang, Aihua Gu, Feng Chen, Liping Xie, Zhengrong Huang, Hong Wang, Yong Ji
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2022-06-01
Edice:Redox Biology
Témata:
Heat shock protein 90
S-nitrosylation
Atherosclerosis
Oxidative stress
Endothelial dysfunction
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2213231722000623
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