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Improved Lentiviral Gene Delivery to Mouse Liver by Hydrodynamic Vector Injection through Tail Vein

Delivery of genes to mouse liver is routinely accomplished by tail-vein injections of viral vectors or naked plasmid DNA. While viral vectors are typically injected in a low-pressure and -volume fashion, uptake of naked plasmid DNA to hepatocytes is facilitated by high pressure and volumes, also kno...

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Detalhes bibliográficos
Main Authors: Trine Dalsgaard, Claudia R. Cecchi, Anne Louise Askou, Rasmus O. Bak, Pernille O. Andersen, David Hougaard, Thomas G. Jensen, Frederik Dagnæs-Hansen, Jacob Giehm Mikkelsen, Thomas J. Corydon, Lars Aagaard
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018-09-01
Colecção:Molecular Therapy: Nucleic Acids
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2162253118301458
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