Reactive Astrocytes Derived From Human Induced Pluripotent Stem Cells Suppress Oligodendrocyte Precursor Cell Differentiation

Astrocytes are instrumental in maintaining central nervous system (CNS) homeostasis and responding to injury. A major limitation of studying neurodegenerative diseases like multiple sclerosis (MS) is lack of human pathological specimens obtained during the acute stages, thereby relegating research t...

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Main Authors: Matthew D. Smith, Xitiz Chamling, Alexander J. Gill, Hector Martinez, Weifeng Li, Kathryn C. Fitzgerald, Elias S. Sotirchos, Dorota Moroziewicz, Lauren Bauer, Daniel Paull, Marjan Gharagozloo, Pavan Bhargava, Donald J. Zack, Valentina Fossati, Peter A. Calabresi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Molecular Neuroscience
Assuntos:
multiple sclerosis
astrocyte
oligodendrocyte
neurotoxicity
induced pluripotent stem cell (iPSC)
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fnmol.2022.874299/full
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