Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology

<p>Abstract</p> <p>Background</p> <p>A growing body of evidence indicates that inflammation is one of the earliest neuropathological events in Alzheimer's disease. Accordingly, we have recently shown the occurrence of an early, pro-inflammatory reaction in the hipp...

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Detalhes bibliográficos
Main Authors: Ferretti Maria, Allard Simon, Partridge Vanessa, Ducatenzeiler Adriana, Cuello A Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2012-04-01
Colecção:Journal of Neuroinflammation
Assuntos:
Alzheimer
Aβ-oligomers
BACE
iNOS
Microglia
Minocycline
NFkB
Acesso em linha:http://www.jneuroinflammation.com/content/9/1/62
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