BACE1 inhibition by microdose lithium formulation NP03 rescues memory loss and early stage amyloid neuropathology

Lithium is first-line therapy for bipolar affective disorder and has recently been shown to have protective effects in populations at risk for Alzheimer’s disease (AD). However, the mechanism underlying this protection is poorly understood and consequently limits its possible therapeutic application...

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Detalhes bibliográficos
Publicado no:Transl Psychiatry
Main Authors: Wilson, E N, Do Carmo, S, Iulita, M F, Hall, H, Ducatenzeiler, A, Marks, A R, Allard, S, Jia, D T, Windheim, J, Cuello, A C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5611736/
https://ncbi.nlm.nih.gov/pubmed/28763060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2017.169
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