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Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology
BACKGROUND: A growing body of evidence indicates that inflammation is one of the earliest neuropathological events in Alzheimer's disease. Accordingly, we have recently shown the occurrence of an early, pro-inflammatory reaction in the hippocampus of young, three-month-old transgenic McGill-Thy...
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Autori principali: | , , , , |
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Natura: | Artigo |
Lingua: | Inglês |
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BioMed Central
2012
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Soggetti: | |
Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3352127/ https://ncbi.nlm.nih.gov/pubmed/22472085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-62 |
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