Design of a Prospective Study on Pharmacokinetic-Guided Dosing of Prophylactic Factor Replacement in Hemophilia A and B (OPTI-CLOT TARGET Study)

In resource-rich countries, almost all severe hemophilia patients receive prophylactic replacement therapy with factor concentrates to prevent spontaneous bleeding in joints and muscles to decrease the development of arthropathy and risk of long-term disability. Pharmacokinetic (PK)-guided dosing ca...

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Main Authors: Tine M.H.J. Goedhart, Laura H. Bukkems, Michiel Coppens, Karin J. Fijnvandraat, Saskia E.M. Schols, Roger E.G. Schutgens, Jeroen Eikenboom, Floor C.J.I. Heubel-Moenen, Paula F. Ypma, L. Nieuwenhuizen, K. Meijer, Frank W. G. Leebeek, Ron A.A. Mathôt, Marjon H. Cnossen
Formato: Artigo
Idioma:Inglês
Publicado em: Georg Thieme Verlag KG 2022-01-01
Colecção:TH Open
Assuntos:
hemophilia
pharmacokinetics
factor viii
factor ix
prophylaxis
Acesso em linha:http://www.thieme-connect.de/DOI/DOI?10.1055/a-1760-0105
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