MHC Class II and Non-MHC Class II Genes Differentially Influence Humoral Immunity to Bacillus anthracis Lethal Factor and Protective Antigen

Anthrax Lethal Toxin consists of Protective Antigen (PA) and Lethal Factor (LF), and current vaccination strategies focus on eliciting antibodies to PA. In human vaccination, the response to PA can vary greatly, and the response is often directed toward non-neutralizing epitopes. Variable vaccine re...

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Dettagli Bibliografici
Autori principali: Judith A. James, A. Darise Farris, Melissa L. Nguyen, Philip M. Cox, Sherry R. Crowe, Eric K. Dumas, Sridevi Kurella, Jonathan J. Hunt, Lori Garman
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2012-12-01
Serie:Toxins
Soggetti:
Bacillus anthracis
protective antigen
lethal factor
vaccine
antibody response
MHC class II
mouse
genetic background
Accesso online:http://www.mdpi.com/2072-6651/4/12/1451
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