Bacillus anthracis Edema Toxin Inhibits Efferocytosis in Human Macrophages and Alters Efferocytic Receptor Signaling

The Bacillus anthracis Edema Toxin (ET), composed of a Protective Antigen (PA) and the Edema Factor (EF), is a cellular adenylate cyclase that alters host responses by elevating cyclic adenosine monophosphate (cAMP) to supraphysiologic levels. However, the role of ET in systemic anthrax is unclear....

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Detalhes bibliográficos
Main Authors: Zijian Pan, Eric K. Dumas, Christina Lawrence, Lance Pate, Sherri Longobardi, Xiaodong Wang, Judith A. James, Susan Kovats, A. Darise Farris
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-03-01
Colecção:International Journal of Molecular Sciences
Assuntos:
Bacillus anthracis
Edema Toxin
macrophage
efferocytosis
Acesso em linha:http://www.mdpi.com/1422-0067/20/5/1167
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