Identification of adeno-associated virus variants for gene transfer into human neural cell types by parallel capsid screening

Abstract Human brain cells generated by in vitro cell programming provide exciting prospects for disease modeling, drug discovery and cell therapy. These applications frequently require efficient and clinically compliant tools for genetic modification of the cells. Recombinant adeno-associated virus...

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Hlavní autoři: Lea Jessica Flitsch, Kathleen Börner, Christian Stüllein, Simon Ziegler, Vera Sonntag-Buck, Ellen Wiedtke, Vesselina Semkova, Si Wah Christina Au Yeung, Julia Schlee, Mohamad Hajo, Mona Mathews, Beatrice Stefanie Ludwig, Susanne Kossatz, Horst Kessler, Dirk Grimm, Oliver Brüstle
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Portfolio 2022-05-01
Edice:Scientific Reports
On-line přístup:https://doi.org/10.1038/s41598-022-12404-0
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