Neutralizing Antibodies Against Factor VIII Can Occur Through a Non-Germinal Center Pathway

Humoral immunity to factor VIII (FVIII) represents a significant challenge for the treatment of patients with hemophilia A. Current paradigms indicate that neutralizing antibodies against FVIII (inhibitors) occur through a classical CD4 T cell, germinal center (GC) dependent process. However, clinic...

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Detalhes bibliográficos
Main Authors: Seema R. Patel, Taran S. Lundgren, Wallace Hunter Baldwin, Courtney Cox, Ernest T. Parker, John F. Healey, Ryan P. Jajosky, Patricia E. Zerra, Cassandra D. Josephson, Christopher B. Doering, Sean R. Stowell, Shannon L. Meeks
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Immunology
Assuntos:
hemophilia A
germinal center
B cells
neutralizing antibodies (inhibitors)
extrafollicular pathway
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.880829/full
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