The Landscape of SNCA Transcripts Across Synucleinopathies: New Insights From Long Reads Sequencing Analysis

Dysregulation of alpha-synuclein expression has been implicated in the pathogenesis of synucleinopathies, in particular Parkinson’s Disease (PD) and Dementia with Lewy bodies (DLB). Previous studies have shown that the alternatively spliced isoforms of the SNCA gene are differentially expressed in d...

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Bibliografiske detaljer
Main Authors: Elizabeth Tseng, William J. Rowell, Omolara-Chinue Glenn, Ting Hon, Julio Barrera, Steve Kujawa, Ornit Chiba-Falek
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019-07-01
Serier:Frontiers in Genetics
Fag:
alternative splicing
targeted sequencing
long read sequencing
Parkinson’s Disease
PacBio
Iso-Seq
Online adgang:https://www.frontiersin.org/article/10.3389/fgene.2019.00584/full
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