The MDM2 inhibitor CGM097 combined with the BET inhibitor OTX015 induces cell death and inhibits tumor growth in models of neuroblastoma

Abstract Background Neuroblastoma (NB) is the most common extracranial solid tumor in infants and children, with amplification of the oncogene MYCN being a hallmark of high‐risk disease and poor prognosis. Although less frequent, overexpression of MYC is similarly an indicator of poor prognosis. Mos...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Tyler Maser, Joseph Zagorski, Shannon Kelly, Anna Ostrander, Austin Goodyke, Abhinav Nagulapally, Jeffrey Bond, Yeonhee Park, Giselle Saulnier Sholler
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Wiley 2020-11-01
Reeks:Cancer Medicine
Onderwerpen:
BET
MDM2
MYC
MYCN
neuroblastoma
p53
Online toegang:https://doi.org/10.1002/cam4.3407
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items