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The BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb
None of the currently used anti-HIV-1 agents can effectively eliminate latent HIV-1 reservoirs, which is a major hurdle to a complete cure for AIDS. We report here that a novel oral BET inhibitor OTX015, a thienotriazolodiazepine compound that has entered phase Ib clinical development for advanced h...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4828723/ https://ncbi.nlm.nih.gov/pubmed/27067814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24100 |
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