BET inhibitors RVX-208 and PFI-1 reactivate HIV-1 from latency

Persistent latent reservoir in resting CD4+ T cells is a major obstacle in curing HIV-1 infection. Effective strategies for eradication of the HIV-1 reservoir are urgently needed. We report here for the first time that two BET inhibitors, RVX-208, which has entered phase II clinical trials for diver...

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Publicado no:Sci Rep
Main Authors: Lu, Panpan, Shen, Yinzhong, Yang, He, Wang, Yanan, Jiang, Zhengtao, Yang, Xinyi, Zhong, Yangcheng, Pan, Hanyu, Xu, Jianqing, Lu, Hongzhou, Zhu, Huanzhang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709369/
https://ncbi.nlm.nih.gov/pubmed/29192216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16816-1
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