The MDM2 inhibitor CGM097 combined with the BET inhibitor OTX015 induces cell death and inhibits tumor growth in models of neuroblastoma

Abstract Background Neuroblastoma (NB) is the most common extracranial solid tumor in infants and children, with amplification of the oncogene MYCN being a hallmark of high‐risk disease and poor prognosis. Although less frequent, overexpression of MYC is similarly an indicator of poor prognosis. Mos...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Tyler Maser, Joseph Zagorski, Shannon Kelly, Anna Ostrander, Austin Goodyke, Abhinav Nagulapally, Jeffrey Bond, Yeonhee Park, Giselle Saulnier Sholler
Формат: Artigo
Язык:Inglês
Опубликовано: Wiley 2020-11-01
Серии:Cancer Medicine
Предметы:
BET
MDM2
MYC
MYCN
neuroblastoma
p53
Online-ссылка:https://doi.org/10.1002/cam4.3407
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы