PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence.

Host defense systems employ posttranslational modifications to protect against invading pathogens. Here, we found that protein inhibitor of activated STAT 1 (PIAS1) interacts with the nucleoprotein (NP), polymerase basic protein 1 (PB1), and polymerase basic protein 2 (PB2) of influenza A virus (IAV...

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Hlavní autoři: Guangwen Wang, Yuhui Zhao, Yuan Zhou, Li Jiang, Libin Liang, Fandi Kong, Ya Yan, Xuyuan Wang, Yihan Wang, Xia Wen, Xianying Zeng, Guobin Tian, Guohua Deng, Jianzhong Shi, Liling Liu, Hualan Chen, Chengjun Li
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2022-04-01
Edice:PLoS Pathogens
On-line přístup:https://doi.org/10.1371/journal.ppat.1010446
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