Glycine at Position 622 in PB1 Contributes to the Virulence of H5N1 Avian Influenza Virus in Mice

We isolated two H5N1 viruses, A/duck/Hunan/S4020/2008 (DK/08) and A/chicken/Guangxi/S2039/2009 (CK/09), from live-bird markets during routine surveillance and found that these two viruses are genetically similar but differ in their replication and virulence in mice. The CK/09 virus is lethal for mic...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Feng, Xiaoxiao, Wang, Zeng, Shi, Jianzhong, Deng, Guohua, Kong, Huihui, Tao, Shiyu, Li, Changyao, Liu, Liling, Guan, Yuntao, Chen, Hualan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733975/
https://ncbi.nlm.nih.gov/pubmed/26656683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02387-15
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