The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus Entry

Influenza A virus (IAV) coopts numerous host factors to complete its replication cycle. Here, we identify free fatty acid receptor 2 (FFAR2) as a cofactor for IAV entry into host cells. We found that downregulation of FFAR2 or Ffar2 expression significantly reduced the replication of IAV in A549 or...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Wang, Guangwen, Jiang, Li, Wang, Jinliang, Zhang, Jie, Kong, Fandi, Li, Qibing, Yan, Ya, Huang, Shanyu, Zhao, Yuhui, Liang, Libin, Li, Junping, Sun, Nan, Hu, Yuzhen, Shi, Wenjun, Deng, Guohua, Chen, Pucheng, Liu, Liling, Zeng, Xianying, Tian, Guobin, Bu, Zhigao, Chen, Hualan, Li, Chengjun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6955252/
https://ncbi.nlm.nih.gov/pubmed/31694949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01707-19
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