PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence.

Host defense systems employ posttranslational modifications to protect against invading pathogens. Here, we found that protein inhibitor of activated STAT 1 (PIAS1) interacts with the nucleoprotein (NP), polymerase basic protein 1 (PB1), and polymerase basic protein 2 (PB2) of influenza A virus (IAV...

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Detalhes bibliográficos
Principais autores: Guangwen Wang, Yuhui Zhao, Yuan Zhou, Li Jiang, Libin Liang, Fandi Kong, Ya Yan, Xuyuan Wang, Yihan Wang, Xia Wen, Xianying Zeng, Guobin Tian, Guohua Deng, Jianzhong Shi, Liling Liu, Hualan Chen, Chengjun Li
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2022-04-01
coleção:PLoS Pathogens
Acesso em linha:https://doi.org/10.1371/journal.ppat.1010446
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