Mechanisms of Disulfide Bond Formation in Nascent Polypeptides Entering the Secretory Pathway

Disulphide bonds are an abundant feature of proteins across all domains of life that are important for structure, stability, and function. In eukaryotic cells, a major site of disulphide bond formation is the endoplasmic reticulum (ER). How cysteines correctly pair during polypeptide folding to form...

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Bibliographic Details
Main Authors: Philip J. Robinson, Neil J. Bulleid
Format: Artigo
Language:Inglês
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
disulphide formation
protein folding
protein secretion
protein synthesis
PDI
ER
Online Access:https://www.mdpi.com/2073-4409/9/9/1994
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