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Folding of a single domain protein entering the endoplasmic reticulum precedes disulfide formation

The relationship between protein synthesis, folding, and disulfide formation within the endoplasmic reticulum (ER) is poorly understood. Previous studies have suggested that pre-existing disulfide links are absolutely required to allow protein folding and, conversely, that protein folding occurs pri...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Robinson, Philip J., Pringle, Marie Anne, Woolhead, Cheryl A., Bulleid, Neil J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409466/
https://ncbi.nlm.nih.gov/pubmed/28298446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.780742
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