Pleiotropic association of LIPC variants with lipid and urinary 8-hydroxy deoxyguanosine levels in a Taiwanese population

Abstract Background Hepatic lipase (HL, encoded by LIPC) is a glycoprotein primarily synthesized and secreted by hepatocytes. Previous studies had demonstrated that HL is crucial for reverse cholesterol transport and affects the metabolism, composition, and level of several lipoproteins. In current...

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Detalhes bibliográficos
Main Authors: Ming-Sheng Teng, Semon Wu, Lung-An Hsu, I-Shiang Tzeng, Hsin-Hua Chou, Cheng-Wen Su, Yu-Lin Ko
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-05-01
Colecção:Lipids in Health and Disease
Assuntos:
Hepatic lipase
Single-nucleotide polymorphism
Mediation analysis
Suppression effect
Triglyceride level
High-density lipoprotein cholesterol level
Acesso em linha:http://link.springer.com/article/10.1186/s12944-019-1057-9
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