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Pertuzumab Increases 17-AAG-Induced Degradation of ErbB2, and This Effect Is Further Increased by Combining Pertuzumab with Trastuzumab

ErbB2 is an important oncogenic protein involved in carcinogenesis of, among others, breast, gastric, and ovarian carcinoma. Over-expression of ErbB2 is found in almost 20% of breast cancers, and this results in proliferative and anti-apoptotic signalling. ErbB2 is therefore an important treatment t...

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Detalhes bibliográficos
Main Authors: Juliana Bentes Hughes, Marianne Skeie Rødland, Max Hasmann, Inger Helene Madshus, Espen Stang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2012-06-01
Colecção:Pharmaceuticals
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Acesso em linha:http://www.mdpi.com/1424-8247/5/7/674
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