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Pertuzumab Increases 17-AAG-Induced Degradation of ErbB2, and This Effect Is Further Increased by Combining Pertuzumab with Trastuzumab

ErbB2 is an important oncogenic protein involved in carcinogenesis of, among others, breast, gastric, and ovarian carcinoma. Over-expression of ErbB2 is found in almost 20% of breast cancers, and this results in proliferative and anti-apoptotic signalling. ErbB2 is therefore an important treatment t...

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書誌詳細
主要な著者: Juliana Bentes Hughes, Marianne Skeie Rødland, Max Hasmann, Inger Helene Madshus, Espen Stang
フォーマット: Artigo
言語:Inglês
出版事項: MDPI AG 2012-06-01
シリーズ:Pharmaceuticals
主題:
オンライン・アクセス:http://www.mdpi.com/1424-8247/5/7/674
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