Pertuzumab Increases 17-AAG-Induced Degradation of ErbB2, and This Effect Is Further Increased by Combining Pertuzumab with Trastuzumab

ErbB2 is an important oncogenic protein involved in carcinogenesis of, among others, breast, gastric, and ovarian carcinoma. Over-expression of ErbB2 is found in almost 20% of breast cancers, and this results in proliferative and anti-apoptotic signalling. ErbB2 is therefore an important treatment t...

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Main Authors: Juliana Bentes Hughes, Marianne Skeie Rødland, Max Hasmann, Inger Helene Madshus, Espen Stang
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2012-06-01
Serija:Pharmaceuticals
Teme:
17-AAG
pertuzumab
trastuzumab
Hsp90
ErbB2
Online dostop:http://www.mdpi.com/1424-8247/5/7/674
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