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Hsp90 inhibition and co‐incubation with pertuzumab induce internalization and degradation of trastuzumab: Implications for use of T‐DM1
The receptor tyrosine kinase HER2 is associated with a number of human malignancies and is an important therapeutic target. The antibody‐drug conjugate trastuzumab emtansine (T‐DM1; Kadcyla(®)) is recommended as a first‐line treatment for patients with HER2‐positive metastatic breast cancer. T‐DM1 c...
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| Publicado no: | J Cell Mol Med |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7520337/ https://ncbi.nlm.nih.gov/pubmed/32672902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.15643 |
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