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Antibody CDR loops as ensembles in solution vs. canonical clusters from X-ray structures
In the past decade, the relevance of antibodies as therapeutics has increased substantially. Therefore, structural and functional characterization, in particular of the complementarity-determining regions (CDRs), is crucial to the design and engineering of antibodies with unique binding properties....
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Hauptverfasser: | , , , , |
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Format: | Artigo |
Sprache: | Inglês |
Veröffentlicht: |
Taylor & Francis Group
2020-01-01
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Schriftenreihe: | mAbs |
Schlagworte: | |
Online Zugang: | https://www.tandfonline.com/doi/10.1080/19420862.2020.1744328 |
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