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CDR-H3 loop ensemble in solution – conformational selection upon antibody binding
We analyzed pairs of protein-binding, peptide-binding and hapten-binding antibodies crystallized as complex and in the absence of the antigen with and without conformational differences upon binding in the complementarity-determining region (CDR)-H3 loop. Here, we introduce a molecular dynamics-base...
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| Publicado no: | MAbs |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6748594/ https://ncbi.nlm.nih.gov/pubmed/31148507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1618676 |
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