Transitions of CDR-L3 Loop Canonical Cluster Conformations on the Micro-to-Millisecond Timescale

Sequence and structural diversity of antibodies are concentrated on six hypervariable loops, also known as the complementarity determining regions (CDRs). Five of six antibody CDR loops presumably adopt a so-called canonical structure out of a limited number of conformations. However, here we show f...

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Vydáno v:Front Immunol
Hlavní autoři: Fernández-Quintero, Monica L., Math, Barbara A., Loeffler, Johannes R., Liedl, Klaus R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877499/
https://ncbi.nlm.nih.gov/pubmed/31803187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02652
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